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According to the efficacy estimand, mean weight change from SURMOUNT-5 baseline to the end of ATTAIN-MAINTAIN was 16.5% with orforglipron compared with 12.6% with placebo

Its getting harder and harder to rationalize not being on these drugs

Doctors usually start with a lower dose and gradually increase it based on how well the patient tolerates the medication

277 The reported variation in the weight loss for the different GLP-1 analogues currently used to treat T2D is possibly related to their ability to penetrate the CNS, allowing for central GLP-1R binding

Reducing portion sizes and eating slowly helps manage gastrointestinal symptoms