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APE1 was also one of the many non-regulatory proteins involved in cancer survival signaling pathways, and could be used as a therapeutic target in the treatment of multiple types of tumor cells [24]

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Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition [doi: 10.1038/nature24297]

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These enzymes are considered to play a primary role in removing cells identified as damaged or dysfunctional within an organism