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"Questions & Answers: April 15, 2006"

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Possible causes: dead space accumulation (discussed above), inaccurate water volume at reconstitution (more water means more dilute, means more volume per dose, means fewer doses from the same amount of peptide), or air in the vial displacing solution

In this study, the high molecular weight HA used in combination with AOD9604 may have further supported chondrocyte survival and matrix synthesis, contributing to the observed improvements in cartilage morphology and function