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There is still a lack of preclinical in vitro bloodbrain barrier models that can perfectly mimic the brain microenvironment, leading to limitations in the effectiveness of in vitro screening and practical application of nanomedicine carriers

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The Oral Alternative: Why NAC Wins on Evidence If your primary goal is raising intracellular glutathione, N-acetylcysteine (NAC) has stronger clinical evidence and has far more predictable pharmacokinetics than SubQ glutathione injection

GigaScience 9 , giaa151 (2020)