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These agents preferentially lower fasting and postprandial hyperglycemia according to their pharmacokinetic (PK) characteristics, while also being associated with body weight loss [1,2,3,4,5,6]

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Effects of a small-molecule NNMT inhibitor on body weight, glucose tolerance and insulin sensitivity in diet-induced obese mice

Hypoxic conditions can upregulate GPI activity, and in RA synovial tissue cells, upregulated GPI can induce RA angiogenesis by increasing the expression of HIF-1 and VEGF (213, 214)