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However, beyond weight gain, obesity involves a series of obesity-related diseases, which in patients with PWS can have a stronger impact, considering the early onset of obesity, the difficulties in adhering to lifestyle changes, use of psychotropic medications, and the inability to communicate some symptoms linked to mental retardation [24, 28]

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H&E staining showed a greater frequency of smaller adipocytes, while IHC staining showed more UCP-1 (Fig

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HE REFERRED TO it as his little science experiment. Once a week, Bill, 45, would wash his hands, sterilize his desk, and lay out the syringes he bought from Amazon as he prepared to inject his drug cocktail