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Even with the application of the most advanced and perfect treatments available, more than 50% of survivors with cardio-cerebrovascular accidents may still be unable to take care of themselves completely (Lu et al., 2021)

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Typical probiotics such as Lactobacillus and Bifidobacterium can improve metabolic efficiency and reduce oxidative stress and inflammation (154), and the proliferation of harmful bacteria (such as Enterococcus and Streptococcus ) can produce toxins (such as hemolysins and cytotoxins) or stimulate the intestinal immune system, leading to local or systemic inflammatory responses (155)

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This interaction is at least partially influenced by glucose levels, suggesting a metabolic link in the modulation of circadian function [104]