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Activation of S1PR2 by specific BAs, particularly conjugated BAs such as taurocholic acid (TCA), stimulates the RhoA/ROCK1 signaling axis in macrophages, facilitating M1 polarization and NLRP3 inflammasome activation

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For a reader weighing MEDVi, the takeaway is narrow: the company received a regulatory communication about how it described its compounded medications, not about the safety of the medications themselves

Fact: While the dry powder might be stable at room temperature for short periods, the liquid version must be refrigerated to prevent degradation and bacterial growth

, 2017, 60.9: 562-564