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Cutaneous melanoma is an extremely aggressive malignant tumor arising from melanocytes and accounting some 15% of all cancers

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Melatonin is associated with a decrease in the expression of Rho-associated protein 1 (ROCK1) and myosin light chain kinase (MLCK), in the presence of Ca 2+ /calmodulin and ATP MLCK catalyzes the phosphorylation of myosin light chain (MLC)

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