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Participants who lost 15 percent or more of their body weight saw larger reductions in systolic blood pressure (around 10 mmHg versus 4 mmHg in those losing less) and diastolic pressure (around 4 mmHg versus 1 mmHg), with greater falls in C-reactive protein and non-HDL cholesterol as well (Patient Care Online, 2026)

Use a new needle each time, to prevent blockages and infections

Side effects peak as doses increase toward maintenance levels

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Compounded Alternatives: What You Need to Know Brand-name Wegovy and Ozempic are FDA-approved semaglutide products manufactured by pharmaceutical companies, but they require insurance coverage or significant out-of-pocket costs that often exceed $900 monthly