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The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus

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Human evidence remains limited and exploratory

Nevertheless, persistent or severe diarrhoea warrants clinical assessment, particularly given the risk of dehydration and electrolyte imbalance

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This development has led to the introduction of several GLP-1 receptor agonists and DPP-4 inhibitors on the market [3], which are featured prominently in current recommendations because of their effectiveness, safety and proven cardiovascular benefits [33]