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Phenobarbital-induced liver enlargement is associated with initial transient hyperplasia in rodents as an early event after treatment and a substantial proliferation of smooth endoplasmic reticulum, causing hepatocellular hypertrophy

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Their mechanisms of action arent always clearly defined

Small-molecule labelling using click chemistry In-cell click labelling Cells on coverslips were treated as indicated with cDFO (in-house, 100 M, 15 min), cLip-1 (in-house, 1 M, 1 h or 2 h), metcLip-1 (in-house, 10 M, 1 h), alcLip-1 (in-house, 10 M, 1 h) or cCW (1 M, 1 h), then fixed and permeabilized as indicated in the section Fluorescence imaging