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Moreover, experiments in rat renal tubular (NRK-52E) cells showed the accumulation of fluorescently labelled polymyxins in both the ER and mitochondrial compartments 53

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Efficacy: Semaglutide has superior reductions in HbA1c and body weight compared to other agents, while tirzepatide, a dual GLP-1/GIP receptor agonist, shows even greater efficacy but with higher rates of adverse events

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