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Because the strength of anisotropic interactions is orientation-dependent, the mechanical alignment of the sample at a particular angle (called the magic angle) with respect to the static magnetic field and spinning around the tilted axis averages out these anisotropic interactions, resulting in more resolved peaks and enabling so-called high-resolution magic-angle spinning (MAS) solid-state NMR studies ( As a consequence, many biological systems usually challenging for crystallography and solution NMR constitute nowadays targets of choice for SSNMR investigations