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115 In addition, liver insulin also effectively regulates lipid metabolism primarily by promoting cleavage and nuclear translocation of the sterol regulatory element binding protein 1c (SREBP-1c) 116,117 that activates lipogenesis in hepatocytes

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If weight increases by more than 5% from your lowest point, consider restarting at a low maintenance dose rather than waiting for larger regain

10.1056/NEJMoa2401943 61 MaB.WangX.RenH.LiY.ZhangH.YangM.et al (2023)

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