cagrilintide clinical trials results New in the August 14, 2025, issue of NEJM: ⁣ ⁣ Cagrilintide–Semaglutide for Overweight or Obesity (REDEFINE 1 phase 3a trial)⁣ ⁣ Cagrilintide–Semaglutide for Overweight and Diabetes (REDEFINE 2 phase 3a trial)⁣ ⁣ Efficacy and safety of once-weekly

This concern creates specific usage limitations for individuals with Wilson's disease or other copper metabolism disorders

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For patients diagnosed with a vitamin B12 deficiencyespecially when caused by problems with absorption in the digestive tract (such as pernicious anemia, certain gastrointestinal conditions, or after specific surgeries)oral supplements may not be effective

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side-effect profile Considerations For example, amylin-based therapies can cause digestive effects, including nausea and vomiting, particularly during initiation or dose escalation