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Its given weekly by injection and is often compared to GLP-1s because the effects (and side effects) overlap, but it tends to have stronger A1c reduction and weight loss effects

Annese, V

We often see that the effect feels clearer when you: keep track of calories avoid overeating choose smaller but more nutrient-dense portions keep a stable protein intake eat regularly rather than spontaneously Conversely, large meals, very unhealthy food or unstructured eating can drown out the medication for some users

Current understanding of dysbiosis in disease in human and animal models

This dual-action approach enhances insulin sensitivity and further reduces appetite and fat storage, often leading to even more substantial weight loss than GLP-1-only therapies

Once-weekly trelagliptin versus daily alogliptin in Japanese patients with type 2 diabetes: a randomised, double-blind, phase 3, non-inferiority study