Adipose tissue is not merely a storage depot
First, the quality of the PCOS GLP-1 evidence is generally moderate to low: trials are small, short, heterogeneous in design and comparator, and often use surrogate rather than hard reproductive endpoints, so even the class with actual PCOS data is not on firm regulatory footing for this use
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Im going to start with, tell us your story
The combined activation of all three receptors creates a synergistic effect: appetite is suppressed through GLP-1 and GIP activity, while the glucagon receptor increases fat burning and energy expenditure
Common side effects include nausea, vomiting, diarrhoea, and abdominal discomfort