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Examples include pain or irritation from brushing your hair or wearing a shirt

These mechanisms are studied in cell-culture and animal models, not in humans

However, when gallstones obstruct the bile ducts or cause inflammation, they can produce characteristic symptoms that warrant medical attention

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doi: 10.3389/fimmu.2026.1763817 Received 09 December 2025 Revised 24 January 2026 Accepted 02 February 2026 Published 18 February 2026 Volume 17 - 2026 Edited by Panida Sittipo, Burapha University, Thailand Reviewed by Maria Touraki, Aristotle University of Thessaloniki, Greece Victor Baba Oti, Griffith University, Australia Updates Copyright 2026 Qian, Li, Ye, Lu, Sha, Zhang, Xu, Song and Li