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However, if the goal is specifically treating post-acne marks, sun spots, or melasma patches defined areas of hyperpigmentation topical kojic acid is the more targeted, better-evidenced, and significantly lower-risk approach

Pandi-Perumal SR, Trakht I, Srinivasan V et al (2008) Physiological effects of melatonin: role of melatonin receptors and signal transduction pathways

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Trial Data Sparks Interest: Phase 3 results for retatrutide reveal substantial weight reductions up to 28 percent at higher doses, with many participants achieving outcomes comparable to surgical interventions

74 KoppulaP.LeiG.ZhangY.YanY.MaoC.KondiparthiL.et al (2022)