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Trial evidence supports larger mean weight reduction on semaglutide at 68 weeks compared to phentermine at 12 weeks

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Pflugers Arch - Eur J Physiol 476 , 11251143 (2024)

The dual agonism approach was controversial at its introduction GIP receptor agonism in isolation was considered to have limited metabolic utility based on earlier research but Tirzepatide's clinical and preclinical data have firmly established the synergistic value of GIPR + GLP-1R co-activation