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GSH treatment is a promising approach, but high doses of GSH are necessary to achieve a therapeutic efficacy, due to its poor transport into the cells and tissues

An underactive thyroid (hypothyroidism) often leads to constipation and bloating, while an overactive thyroid (hyperthyroidism) can cause frequent bowel movements

This triggers downstream signaling pathways (e.g., NF-B and MAPK), driving the massive release of pro-inflammatory cytokines, including IL-1, IL-6, and TNF- (167170)

Overweight, obesity, and depression: a systematic review and meta-analysis of longitudinal studies

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If these side effects are not intolerable, then the patient should be guided through this period