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336,337 The inhibitors of IDO are currently under investigation in clinical trials for solid cancer to enhance primary anticancer therapy, including antibodies and immune checkpoint inhibitors

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But the field still faces a practical gap: even as clinical candidates emerge, it remains unclear whether systemic small-molecule KHK inhibition will translate into durable patient benefit

Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS)

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