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Eli Lillys Zepbound, for example, has garnered attention for its ability to deliver significant weight loss and improved glycemic control, while potentially minimizing some of the gastrointestinal discomfort seen with other agents

When p53 transcriptional activity in response to 5-FU treatment was measured, the mRNA and protein levels of p21, which is a p53 target gene, were decreased in the GST WT -p53-expressing cells

doi: 10.1542/peds.2015-0129 81

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Call your healthcare provider or seek emergency care if you experience: Severe or persistent nausea or vomiting: This could lead to dehydration or interfere with your ability to take other medications

If additional glycemic control is needed after at least 4 weeks on a 0.5 mg dose, the dosage may be increased to 1 mg or 2 mg once weekly