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6.4 Summary of RCTs In the RIPENACTB trial, adjunct NAC treatment with 1,200 mg twice a day in hospitalized HIV/TB patients significantly reduced circulating lipid peroxidation (malondialdehyde (MDA) levels by approximately 40%50%) and increased antioxidant defenses, including glutathione (GSH, by approximately 30%40%), compared to baseline and the standard care group

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Glutathione neutralizes reactive oxygen species directly and regenerates other antioxidants including vitamins C and E after theyve been oxidized

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Second, measuring enzymatic activity is a time-consuming process