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In contrast, the STEP trials for semaglutide (20212022) demonstrated average weight reductions of 1015 kg (2233 lbs) in the first 16 weeks alone, with continued loss extending to 68 weeks

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Prednisone, like other corticosteroids should not be administered concomitantly with: - Barbiturates, carbamazepine, phenytoin, rifampin or ephedrine: these drugs enhance the metabolism of corticosteroids reducing their therapeutic action

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