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By applying these inclusion and exclusion criteria, the review aimed to ensure the inclusion of relevant and high-quality studies that provide valuable insights into the role of oxidative stress, antioxidant interventions, and associated clinical trials in trisomy 21 or Down syndrome

doi: 10.1186/s12974-019-1474-8

f , i , Proposed fragmentation pathways of flavan-3,3,4-triol ( 4 ) for fragments observed in negative ( f ) and positive ( i ) ion ESI-MS

However, the timing of supplementation is critical to maximizing its benefits

This conversion can trigger proteotoxic stress and abnormalities in enzymes containing sulfhydryl groups, highlighting the significance of maintaining optimal glutathione levels for overall health and neurological function

PMID: 38432109 PLoS Genet A C