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Some patients also benefit from stepping down to a microdose GLP-1 protocol ($129/month flat) if they experienced side effects at higher doses but still need appetite support

A research piece in JAMA from January 2025, examining over 125,000 individuals who were overweight or obese, indicated that almost 47% of participants with type 2 diabetes and 65% without diabetes ceased using their prescribed GLP-1s within twelve months of initiation