Additionally, these modifications may induce significant toxicity by triggering immune responses 46,47
Recommendation: To prevent darkening, follow up with SPF50 sunblock during and after brightening treatment to maintain even skin
M98K-OPTN induces transferrin receptor degradation and RAB12-mediated autophagic death in retinal ganglion cells
Creatine, due to its antioxidant and anti-excitotoxic properties, has been found to have a significant therapeutic effect in mouse models of ALS (Klopstock 2011
doi: 10.3390/cancers15051552 79 LinLLiLChenXZengBLinT
Similar adaptive mechanisms have been observed in other neurological conditions, where reduced EAAT2 levels in certain brain regions appear to help maintain E/I balance (O'Donovan et al., 2017