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A study has shown that up to 67% of people who stop using GLP-1 RAs regain a significant portion of the weight they lost, on average, regaining about two-thirds of their weight within a year

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Thus, the inability to account for inhibition of IGF-2 binding to the IGF-1R is an important limitation in this study, which should be considered when assessing outcomes from human trials using IGF-1R mAbs

These differences between groups were addressed using PSM

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