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Phenotypic changes in LSEC are one of the key events in the progression of MASLD in humans, suggesting that the progression of MASLD inflammation, hepatic fibrosis and impaired hepatic lipid metabolism may affect the expression of Fc receptor IIb (FcR IIb) and macrophage function in LSEC (87)

FDA approval is expected in 2026

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Targeting HO-1 may provide new strategies for the prevention and treatment of diabetes