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By the end of the trial, average total weight reductions were: 5 mg dose: 16.0% (about 35.5 lb) 10 mg dose: 21.4% (about 48.9 lb) 15 mg dose: 22.5% (about 52.0 lb) Placebo: 2.4% (about 5.3 lb) The figure highlights steady, ongoing weight loss with tirzepatide, in contrast to minimal change with placebo