Preclinical research has indicated that Withania somnifera elicits antidepressant-like effects that are comparable to those of imipramine and fluoxetine, thereby corroborating its involvement in serotonergic and noradrenergic signaling cascades (78)
Ohnuma K., HiranoKodaira M., Bannai M., et al., A BroadSpectrum Peptide Screening Method Using an Optimized SolidPhase Extraction and Liquid ChromatographyHighField Asymmetric Ion Mobility SpectrometryMass Spectrometry for Doping Control in Equine Urine, Analytical Methods 16, no
Hematological changes, including elevated blood levels of homocysteine and methylmalonic acid, are diagnostic of vitamin B 12 deficiency
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Severe toxicity is also more likely in people whose intracellular stores of glutathione are depleted as a result of starvation or protein malnutrition
Ersahin, D., Doddamane, I