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We dont yet know the full impact of 510 years of continuous use

Yadav SK, Singla-Pareek SL, Reddy MK, Sopory SK (2005) Transgenic tobacco plants overexpressing glyoxalase enzymes resist an increase in methylglyoxal and maintain higher reduced glutathione levels under salinity stress

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By contrast, real-world persistence drops off a cliff fairly early on

In low oxygen situations (hypoxia, ischaemia) lactate increases several-fold as its conversion from pyruvate in the lactate dehydrogenase reaction is essential to regenerate NADH needed to maintain glycolysis [59]

There might be temporary increases in liver enzyme levels so it's important to interpret the results carefully