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At these sub-zero temperatures, any residual molecular motion is slowed to a near halt, and the risk of degradation over time becomes almost negligible

The physiological adaptations over time need to be considered

In addition, hydroxocobalamin may be used as part of the treatment for cyanide poisoning (as an antidote), although in such emergency cases very high doses are administered under hospital care

Key contraindications may include hypersensitivity to peptides, active malignancy and unmonitored self-medication

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Norepinephrine dysregulates the immune response and compromises host defense during sepsis