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Moreover, some NAD + precursors have shown side effects, such as the use of NA at certain doses that might be limited due to skin flushing or induction of insulin resistance 332,333

Cell Death Dis 13:116 Funding Study supported by Self-funded research project of Health Commission of Guangxi Zhuang Autonomous Region (Z-A20230076)

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Efficacy and safety of liposomeencapsulated 4nbutylresorcinol 0.1% cream for the treatment of melasma: a randomized controlled splitface trial

(1985) reported that tamoxifen, the nonsteroidal anti-estrogen used to treat breast cancer, inhibited PKC, which was then known to bind with high affinity to tumor-promoting phorbol esters (OBrian et al., 1985)

Box plot statistics for panels c , e , and f are reported in the source data