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Its influence on peptide regulation and aging processes extends to improved sleep quality and better regulation of circadian rhythms, which are essential for maintaining overall health and longevity

The intensive treatment of the multiple risk factors reduces the development/progression of renal disease18 which is why guidelines insist on comprehensive management of the patient with diabetes (glycemic control and control of cardiovascular risk factors, use of renin-angiotensin system inhibitors, as well as lifestyle changes, including smoking cessation or weight loss in overweight/obese individuals, among others).19 However, the residual renal risk remains very high in optimally treated patients.20 More recently, iSGLT2 has been shown to reduce the risk of cardiovascular and renal events, but still, the residual risk of renal disease progression remains high.21,22 Nevertheless, although the rate of diabetes-related complications (such as myocardial infarction, stroke, lower limb amputations or mortality) have decreased significantly in recent decades, this is not the same for CKD patients requiring renal replacement therapy attributed to diabetic kidney disease (DKD).23 Therefore new treatments are needed that improve glycemic control independently of GFR, with a low risk of hypoglycemia and able to reduce cardiovascular and renal risk in this population

Body-mass index and symptoms of gastroesophageal reflux in women

2000 Sep;47(3):397-403

doi: 10.1016/j.redox.2023.103008

doi: 10.1038/ejhg.2009.187 367 UlrichG.SalvadA.BoersemaP.CalT.FoglieniC.SolaM.et al