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With the presence of three proline residues (P195 ECL1 , P197 ECL1 and P199 ECL1 ), the ECL1 of GIPR presents a notable conformational adaptability in recognition of different agonists, a phenomenon that was not seen with that of GLP-1R and GCGR as their binding pockets exhibit less flexibility when recognizing the peptides through a combination of common segment that contributes to conserved interactions and distinct sequences that govern receptor selectivity
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