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Cancer Cell 22 , 3650 (2012)

In rat cardiomyocytes, zinc overload elevates ROS and disrupts mitochondrial membrane potential, triggering PINK1/Parkin-mediated mitophagy and impairing mitochondrial dynamics and biogenesis, with mitofusin 2 (Mfn2) playing a protective role in mitigating zinc-induced mitochondrial damage 151

Deamidation alters asparagine and glutamine residues, changing the peptide sequence itself