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Acute insulin application in the ventral tegmental area in vitro diminishes somatodendritic dopamine levels via increased dopamine transporter activity, mediated by PI3K and mammalian target of rapamycin (mTOR) signaling pathways [90]

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2a and b)

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Asterholm IW, Mundy DI, Weng J, Anderson RG, Scherer PE (2012) Altered mitochondrial function and metabolic inflexibility associated with loss of caveolin-1

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Complete discontinuation is possible but requires structured metabolic transition over 612 months, including gradual dose tapering, increased dietary protein (1.62.2g per kg daily), resistance training four times weekly, and close weight monitoring

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