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S2CID 86144218

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2 Methodology 2.1 Search strategy This scoping review was conducted in accordance with the preferred reporting items for systematic reviews and meta-analyses extended for scoping reviews (PRISMA-ScR)

Current status: TRIUMPH-4 results available: December 2025 readout showing 28.7% weight loss at 68 weeks (Giblin et al., PMID 41090431) Additional TRIUMPH trials: Expected to report results through 2026, including TRIUMPH-Outcomes (cardiovascular endpoints, NCT06383390, completion Feb 2029) NDA submission timing: Eli Lilly must compile the full trial package before submitting