Patients with low GLP1R sensitivity may need higher dosesbut with slower escalation to minimize sulfur burpswhile those with high sensitivity often succeed on microdose protocols ($129/mo)
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Continuous glucose monitoring data showed time in range of 88.9% with CagriSema compared to 76.2% with semaglutide and 71.7% with cagrilintide
In summary, GLP-2 within the CNS likely regulates membrane excitability and nuclear transcription of POMC neurons
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