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However, a surprising discovery revealed that cellular senescence may elicit stemness, and that this mechanism plays an important role in cancer relapse [ 4 , 5 ]

L68Q variant expression constructs Human embryonic kidney 293 (HEK-239T) cells were obtained from ATCC (Manassas, Virginia) and grown at 37 C in Dulbeccos modified Eagles medium (DMEM) supplemented with 10% fetal bovine serum

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The fact that benign thyroid nodules are highly prevalent in the general population provides one challenge, in and of itself, to judgment regarding when surgical intervention or other invasive treatments, such as thyroidectomy, is required (Castillo-Gonzalez et al