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The causal link is not definitive, but practice guidelines recommend cautious use in patients with a history of pancreatitis and prompt evaluation of abdominal pain

Any slight increase in the scale is often due to water retention from inflammation or changes in activity levels while sick

Dysfunction within the CNS Brain imaging studies have demonstrated an association between PDPN and structural changes in key somatosensory regions, such as the thalamus and somatosensory cortex, and altered functional connectivity within ascending pain pathways and cortical regions involved in pain processing

More Parameters tested in the 96-well plate GST P1-1 inhibition assay

Treatment begins at a starter dose of 0.25mg, which is not a maintenance dose, and increases gradually over several months