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The pressure in the pulmonary circuit may ultimately exceed the systemic pressure causing reversal of blood flow from the right side of the circulation to the left (Eisenmenger syndrome)

Saha, T., & Chatterjee, M

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Immune cells from aged versus nonaged adult killifish display different functional responses to LPS stimulation and have increased markers of senescence To test whether the molecular and cellular changes we observed in the killifish kidney marrow during aging are associated with an impaired immune cells response in vitro, we adopted an assay that measures immune cell activation in the presence of LPS, a potent immune stimulator 54 (Fig