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Increased activity of ASM is a hallmark of MDD metabolic alterations, which promotes the breakdown of sphingolipids into ceramides, which in turn induces neuroinflammation (25), leading to neuronal apoptosis and impaired synaptic plasticity

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For SGLT2i use, 75.4% and 99.6% of simulations produced cost-effective simulations for the total and secondary prevention populations, respectively

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As with any supplement, those with preexisting medical conditions or taking other medications should consult a healthcare professional before starting

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