There were signifcant diferences in TB, DB, ALP, TA, IgM, interface activity, and ductopenia grade between patients with CK7Hs and CK7+Hs (2+) (P 60K), Boston Pharmaceutical ( 2 years follow-up, final patient diagnoses included AIH (n=6), metabolic dysfunction-associated (MASH) (n=10), simple steatosis (n=3), AIH overlap syndromes (n=3), other non-AIH liver diseases or resolving injury states (n=5), and normal controls (n=6)
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10.1038/s41423-022-00934-6 96 JoshiD
These results suggested that Reg1 loss promoted hepatocyte-derived ICC formation via oncogenic CSF1+CD11b+ myeloid cells
Small molecule PAD4 inhibitors, including CI-amidine and GSK484, effectively suppress chromatin decondensation, thereby reducing inflammatory signaling, autoimmunity progression, and tumor dissemination in preclinical studies
GLP-1 Receptor Agonists: Promising Therapeutic Targets for Alcohol Use Disorder