this represents the most advanced program targeting cognitive enhancement through longevity pathways Combination approaches: GLP-1 agonists combined with anti-amyloid therapies or mitochondrial-targeted agents may address multiple pathological pathways
Endothelial Hb haem iron in the Fe 3+ state enables NO signaling, while this signaling is terminated when Hb is converted to the Fe 2+ state by endothelial CYB5R3 (cytochrome b5 reductase 3)
This dual interaction promotes vasodilation, improves local blood flow, and supports endothelial repair
however, current treatment methods, including surgery, chemotherapy, radiotherapy, targeted therapies, and immunotherapy, demonstrate limited success in effectively treating cancer [176]
& Asberg, M
Frontiers in Endocrinology (2023)