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Pharmacological inhibition of USP1 similarly reduced BMAL1 protein levels both in vitro and in mouse tissues, further confirming its role in regulating BMAL1 stability (Hu et al., 2024)

robust human dose-finding data remain limited

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8 weeks (1 vial): 3 mL 1 10 mL bottle 12 weeks (1 vial): 3 mL 1 10 mL bottle 16 weeks (2 vials): 6 mL 1 10 mL bottle 20 weeks (3 vials): 9 mL 1 10 mL bottle Note: Use bacteriostatic water within 28 days after opening [9]

[DOI] [PMC free article] [PubMed] [Google Scholar] 173.Zhang H, Wang Y, He Z