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Berlin, M., Zalups, K

Dave Knapp Nov 12, 2024 4 min read If you've been following the news on GLP-1 medications like Ozempic and Wegovy, you've likely noticed their manufacturer Novo Nordisk, has a lot to say about the risks of compounded semaglutide

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The Key Takeaways: Most common: Nausea (43%), manageable with dietary changes and timing Unique: Dysesthesia (20.9%), mild tingling sensations, not seen with Wegovy/Mounjaro Timeline: Worst during dose escalation (weeks 116), significant improvement after Discontinuation: 18.2% in TRIUMPH-4, 11.3% in TRIUMPH-1 the general obesity population tolerates it better than the osteoarthritis cohort Reversible: Stopping medication reverses side effects For most people with obesity especially severe obesity the 28.328.7% weight loss and associated health benefits outweigh the temporary discomfort during the first few months